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Estradiol

CAS No. : 50-28-2

MCE 站：Estradiol

产品活性：Estradiol 是一种类固醇性激素，对维持女性的生育能力和第二性征至关重要。Estradiol 通过雌激素受体 β (ERβ) 途径上调 IL-6 表达。

研究领域：Others  |  Metabolic Enzyme/Protease

作用靶点：Estrogen Receptor/ERR  |  Endogenous Metabolite

In Vitro: Estradiol causes new dendritic spines and synapses in hippocampal CA1 pyramidal cells. Estradiol increases NMDA receptor binding by 46% in parallel with dendritic spine and synapse density. Estradiol also elevates sensitivity of CA1 pyramidal cells to NMDA receptor-mediated synaptic input and such an effect is correlated with the estradiol-induced increase in dendritic spine density in the apical dendritic tree of these cells. Estradiol reduces Ba²⁺ entry reversibly via Ca²⁺ channels in acutely dissociated and cultured neostriatal neurons. Estradiol also reduces Ba²⁺ currents but is significantly less effective than Estradiol in rat neostriatal neurons.

In Vivo: Estradiol functions in hippocampal synapse density during the estrous cycle in the adult rat.
Estradiol reverses the ovariectomy-induced decrease in spine density. Estradiol in combination with progesterone enhances spine density for 2 to 6 h but decreases following estradiol alone.
Estradiol (0.2 mg/kg; i.p.; C57BL/6 female mice) plus 10 or 20 mg/kg progesterone, enhances memory consolidation in young ovariectomized mice.

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