型号:
产品价格:电议      采购度:1606      原产地:美洲
发布时间:2021/7/16 14:32:30 所属地区:上海 上海市
简要描述:
Histatin 5 TFA 抑制宿主基质金属蛋白酶 MMP-2 和 MMP-9 活性,IC50s 分别为 和 μM。
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MCE 站:Histatin 5 TFA
产品活性:Histatin 5 TFA 抑制宿主基质金属蛋白酶 MMP-2 和 MMP-9 活性,IC50s 分别为 0.57 和 0.25 μM。
研究领域:Metabolic Enzyme/Protease
作用靶点:MMP
In Vitro: Histatin 5 is a member of a family of low-molecular-weight salivary proteins secreted by parotid, submandibular, and sublingual glands. Using biotinylated gelatin as a substrate, Histatin 5 is found to inhibit the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively. To localize the domain responsible for this inhibition, three peptides containing different regions of Histatin 5 are synthesized and tested as inhibitors of MMP-9. Peptides comprising residues 1 to 14 and residues 4 to 15 of Histatin 5 show much lower inhibitory activities (IC50s, 21.4 and 20.5 μM, respectively), while a peptide comprising residues 9 to 22 showed identical activity to Histatin 5 against MMP-9. Kinetic analysis of the inhibition of the Arg-gingipain reveals that Histatin 5 is a competitive inhibitor, affecting only the Km with a Ki of 15 μM . Histatin 5 is an inhibitor of mitochondrial respiration.The human salivary antifungal peptide Histatin 5 is taken up by Candida albicans cells and associates intracellularly with mitochondria. Histatin 5 inhibits respiration of isolated C. albicans mitochondria as well as the respiration of intact blastoconidia in a dose and time-dependent manner. Histatin 5 at a concentration of 33 uM inhibits state 2 respiration.
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更新时间:2024/1/2 10:13:02
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