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Ginsenoside Rk1

CAS No. : 494753-69-4

MCE 站：Ginsenoside Rk1

产品活性：Ginsenoside Rk1 人参皂苷 Rk1 是人参的高温加工提取物。Ginsenoside Rk1 具有抗炎作用，抑制 Jak2/Stat3 信号通路和 NF-κB 的激活。Ginsenoside Rk1 具有抗肿瘤作用，抗血小板聚集活性，抗炎作用，抗胰岛素抵抗，肾保护作用，抗菌作用，认知功能增强，脂质积聚减少和预防骨质疏松症。Ginsenoside Rk1 通过触发细胞内活性氧 (ROS) 生成和阻断 PI3K/Akt 途径诱导细胞凋亡。

研究领域：NF-κB  |  PI3K/Akt/mTOR  |  Epigenetics  |  Stem Cell/Wnt  |  JAK/STAT Signaling  |  Apoptosis

作用靶点：NF-κB  |  PI3K  |  JAK  |  Apoptosis

In Vitro: Ginsenoside Rk1 (0-40 μM; 6 hours) inhibits MCP-1 and TNF-α mRNA induced by lipopolysaccharide (LPS), expression of IL-1β is inhibited at 40 μM.
Ginsenoside Rk1 (0-40 μM; 24 hours) inhibits phosphorylation of JAK2 and STAT3 (Tyr705 and Ser727) in LPS-induced RAW264.7 cells in a dose-dependent manner.
Ginsenoside Rk1 (0-160 μM; 48 hours) results in cell viability significant decrease 75.52 ± 2.51% (40 μM), 52.72 ± 2.54% (80 μM), 17.41 ± 2.94% (120 μM)and 12.63 ± 3.24% (160 μM) compared with control.
Ginsenoside Rk1 (0-120 μM; 24 hours) increases G0/G1 phase proportion accompanied with S and G2/M phase proportion decrease in MDA-MB-231 cells.
Ginsenoside Rk1 (0-120 μM; 24 hours) promotes the percentage of apoptotic cells in a dose-dependent manner, exhibits to reduction of cell number with nucleus fragmentation, condensation and apoptotic body formation.

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