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Paris saponin VII

CAS No. : 68124-04-9

MCE 站：Paris saponin VII

产品活性：Paris saponin VII (Chonglou Saponin VII) 是从延龄草 (Trillium tschonoskii Maxim) 的根和根茎中分离的甾体皂苷。Paris saponin VII 诱导的 K562/ADR 细胞凋亡与 Akt/p38 MAPK 和 P-gp 的抑制有关。Paris saponin VII 减弱线粒体膜电位，增加凋亡相关蛋白 (Bax 和细胞色素 c) 的表达，并降低 Bcl-2，caspase-9，caspase-3，PARP-1 和 p-Akt 的蛋白表达水平。Paris saponin VII 在 K562/ADR 细胞中诱导强烈的自噬，可用于白血病的研究。

研究领域：PI3K/Akt/mTOR  |  MAPK/ERK Pathway  |  Membrane Transporter/Ion Channel  |  Apoptosis  |  Epigenetics  |  Cell Cycle/DNA Damage  |  Autophagy

作用靶点：Akt  |  p38 MAPK  |  P-glycoprotein  |  Bcl-2 Family  |  Caspase  |  PARP  |  Autophagy  |  Apoptosis

In Vitro: Paris saponin VII (Chonglou Saponin VII) inhibits the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. Paris saponin VII significantly suppresses cell proliferation by cell cycle arrest in the G0/G1 phase.

In Vivo: Paris saponin VII (Chonglou Saponin VII) (intravenous administration) significantly enhances anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Cell Cycle/DNA Damage Compound Library  |  Epigenetics Compound Library  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  MAPK Compound Library  |  Membrane Transporter/Ion Channel Compound Library  |  PI3K/Akt/mTOR Compound Library  |  Stem Cell Signaling Compound Library  |  Natural Product Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Differentiation Inducing Compound Library  |  Reprogramming Compound Library  |  Lipid Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Pyroptosis Compound Library  |  Cytoskeleton Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  MG-132  |  LY294002  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Paclitaxel  |  Y-27632 dihydrochloride  |  Venetoclax  |  SB 203580  |  Acetylcysteine  |  Angiotensin II human  |  SP600125  |  5-Fluorouracil  |  Staurosporine  |  Bortezomib  |  Tamoxifen  |  2-Deoxy-D-glucose  |  Gemcitabine  |  Z-VAD(OMe)-FMK  |  Verteporfin  |  Decitabine  |  Actinomycin D  |  Temozolomide  |  BAY 11-7082  |  Etoposide  |  Mitomycin C  |  CCCP  |  DAPT  |  Rotenone

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