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2-Furoyl-LIGRLO-amide

CAS No. : 729589-58-6

MCE 站：2-Furoyl-LIGRLO-amide

产品活性：2-Furoyl-LIGRLO-amide 是一种有效的选择性蛋白酶激活受体2 (PAR2) 激动剂， 其 pD₂ 值为 7.0。

研究领域：GPCR/G Protein

作用靶点：Protease-Activated Receptor (PAR)

In Vitro: 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH₂) is equally effective to and 10 to 25 times more potent than SLIGRLNH₂ for increasing intracellular calcium in cultured human and rat PAR2-expressing cells, respectively.
In bioassays of tissue PAR2 activity, measured as arterial vasodilation and hyperpolarization, 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH₂) is 10 to 300 times more potent than SLIGRL-NH₂. Unlike trans-cinnamoyl-LIGRLO-NH₂, 2-Furoyl-LIGRLO-amide do not cause a prominent non-PAR2-mediated contraction of murine femoral arteries.

In Vivo: Furoyl-LIGRLO-amide (injected intradermally at the nape of the neck; 10 μg; pre-injected) exhibits fewer scratches in response to 2-Furoyl-LIGRLO-amide but not to histamine in Trpv3^-/- mice. But it decreases significantly the number of scratches in WT mice.

相关产品：Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Immunology/Inflammation Compound Library  |  TRAP-6  |  AZ3451  |  PAR-4 Agonist Peptide, amide TFA  |  SCH79797 dihydrochloride  |  Protease-Activated Receptor-2, amide  |  ENMD-1068 hydrochloride  |  SLIGRL-NH2  |  TFLLR-NH2(TFA)  |  GB-110 hydrochloride  |  AC-55541  |  FSLLRY-NH2 TFA  |  Protease-Activated Receptor-4  |  Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA  |  tcY-NH2 TFA  |  2-Furoyl-LIGRLO-amide TFA  |  AC-264613  |  Atopaxar  |  PAR 4 (1-6) (TFA)  |  Parstatin(human)  |  Parstatin(mouse)  |  Protease-Activated Receptor-1, PAR-1 Agonist  |  RWJ-56110 dihydrochloride  |  tcY-NH2  |  TRAP-6 amide

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