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Hederacolchiside A1

CAS No. : 106577-39-3

MCE 站：Hederacolchiside A1

产品活性：Hederacolchiside A1 是从白头翁中分离的，通过调节 PI3K/Akt/mTOR 信号通路诱导凋亡，从而抑制肿瘤细胞的增殖。Hederacolchiside A1 具有抗血吸虫病活性，影响体内和体外的寄生虫生存力。

研究领域：PI3K/Akt/mTOR  |  Anti-infection  |  Apoptosis

作用靶点：PI3K  |  Akt  |  mTOR  |  Parasite  |  Apoptosis

In Vitro: Hederacolchiside A1 reduces the mitochondrial membrane potential and Bcl-2 protein levels, whereas cleaved caspase-3 was higher.
Hederacolchiside A1 effectively inhibits the phosphorylations of phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) .

In Vivo: hederacolchiside A1 (3.0, 4.5, and 6.0?mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model.
Hederacolchiside A1 (3.25, 7.5, and 15.0?mg/kg, ig) can significantly inhibit the weight of tumor in nude mice xenograft tumor models using human breast carcinoma MCF-7 cells.

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