MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

2-Methylcitric acid

CAS No. : 6061-96-7

MCE 站：2-Methylcitric acid

产品活性：2-Methylcitric acid (Methylcitric acid) 是 2- 甲基柠檬酸循环的内源性代谢物。2-Methylcitric acid 在甲基丙二酸血症和丙二酸酸血症中积累并能作为代谢标志物。2-Methylcitric acid 对谷氨酸支持的线粒体中 ADP 刺激和不耦合呼吸作用有明显的抑制作用。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

In Vitro: 2-Methylcitric acid (Methylcitric acid) impairs glutamate metabolism and induces permeability transition in brain mitochondria. 2-Methylcitric acid inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM.
2-Methylcitric acid (1-3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca²⁺-loaded mitochondria supported by different substrates.
2-Methylcitric acid behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis. 2-Methylcitric acid does not significantly impair mitochondrial glutamate transport. 2-Methylcitric acid does not significantly impair glutamate mitochondrial transport in liver mitochondria.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Metabolism/Protease Compound Library  |  Natural Product Library  |  Human Endogenous Metabolite Compound Library  |  Glutamine Metabolism Compound Library  |  Traditional Chinese Medicine Monomer Library  |  Rapamycin  |  3-Methyladenine  |  Acetylcysteine  |  5-Fluorouracil  |  ATP  |  Retinoic acid  |  Hydrocortisone  |  Docetaxel  |  Estradiol  |  Melatonin  |  Nicotinamide  |  Cytarabine  |  Isoprenaline hydrochloride  |  Prostaglandin E2  |  Acetaminophen  |  (-)-Epigallocatechin Gallate  |  β-Nicotinamide mononucleotide  |  Calcitriol  |  DHEA  |  Liothyronine  |  NAD+  |  Luteolin  |  Thymidine  |  Docosahexaenoic Acid  |  Kaempferol  |  Palmitic acid  |  Cyclopamine  |  Genistein  |  L-Glutathione reduced  |  Progesterone

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。