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β-Elemonic acid

CAS No. : 28282-25-9

MCE 站：β-Elemonic acid

产品活性：β-Elemonic acid 是从乳香树中分离得到的三萜。β-Elemonic acid 诱导细胞凋亡，活性氧 (ROS) 和 COX-2 表达，并抑制脯氨酰内肽酶。β-Elemonic acid 具有抗癌和抗炎作用。

研究领域：Apoptosis  |  Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  NF-κB

作用靶点：Apoptosis  |  Reactive Oxygen Species  |  COX

In Vitro: β-elemonic acid (1, 3, 10, 20 ?M; 24 hours) strongly induces human A549 lung cancer cell apoptosis in a dose- and time-dependent manner.
β-elemonic acid (1, 3, 10, 20 ?M; 24 hours) exerts potent cytotoxic effects on human NSCLC A549 cells in a dose-dependent manner. The IC₅₀ value following a 24-h exposure to β-elemonic acid was 6.92 ?M.
β-elemonic acid (20 ?M; 24 hours) results in a cell percentage of 58.01% in the G0/G1 phase.
β-elemonic acid (1, 3, 10, 20 ?M; 24 hours) inhibits phosphorylation of p42/44, MAPK/JNK and p38 in the A549 cells.

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