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Brilliant Black BN

CAS No. : 2519-30-4

MCE 站：Brilliant Black BN

产品活性：Brilliant black BN (E151) 是一种偶氮染料 dye 和一种食品着色剂。Brilliant black BN (E151) 是一种很有前途的抗病毒试剂 (antiviral agent )，通过抑制 EV71 与其细胞脱衣因子亲环素a的相互作用来对抗 EV71 感染。Brilliant black BN (E151) 有潜力用于传染性疾病的相关研究。

研究领域：Anti-infection

作用靶点：Enterovirus

In Vitro: Brilliant black BN (E151) inhibits the interaction between EV71 and its cellular uncoating factor cyclophilin A .
Brilliant black BN (E151) inhibited the infection EV71 -GFP at a concentration of 300 ?M as evidenced from the reduced GFP signals. Brilliant black BN (E151)exhibits the inhibition of EV71 -GFP as a dose-dependent manner in infected RD cells, exhibits an IC₅₀ value of 10.1 ?M.
Brilliant black BN (E151) is able to inhibit all tested 28 EV71, CVA16 and CVA6 strains. In rhabdomyosarcoma cells, 50% inhibitory concentration 29 of the dye E151 for various strains of EV71 ranged from 2.39 ?M to 28.12 ?M ,whereas its 50% cytotoxic concentration is 1870 ?M .

In Vivo: Brilliant black BN (E151)(intraperitoneal injection; 200 mg/kg; 14 days)exhibits mild illness with clinical scores less than 3 and subsequently recovered when compared with PBS-group.All E151 270 treated mice are completely protected throughout the experiment.

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