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Beta-defensin 1, pig

CAS No. :

MCE 站：Beta-defensin 1, pig

产品活性：Beta-defensin 1, pig 是主要在猪舌黏膜中发现的一种抗菌肽。Beta-defensin 1, pig 对大肠杆菌，鼠伤寒沙门氏菌，单核细胞增生性李斯特菌，金黄色葡萄球菌，百日咳博德特氏菌和白色念珠菌等细菌具有活性。

研究领域：Anti-infection

作用靶点：Bacterial

In Vitro: Expression of beta-defensin (pBD-1) mRNA increased from the proximal to the distal part of the intestine whereas pBD-2 expression decreased. The main gene expression sites for pBD-2 are kidney and liver, whereas pBD-1 is mainly expressed in tongue.
An eight-fold increase in pBD-1 mRNA expression is observed upon S. typhimurium infection in the porcine intestinal cell line IPEC J2.
Porcine beta-defensin 1 (pBD-1) also has immunomodulatory activity in porcine peripheral blood mononuclear cells and lymph node cells.

In Vivo: Resistance against respiratory infection with B. pertussis in older piglets is associated with the presence of Porcine beta-defensin 1 (pBD-1) in the upper respiratory tract. Furthermore, treatment with pBD-1 conferred complete protection of newborn piglets from intrapulmonary infection with B. pertussis.

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