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Tetrahydrofolic acid

CAS No. : 135-16-0

MCE 站：Tetrahydrofolic acid

产品活性：Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) 是一种具有生物活性的维生素 B9 叶酸衍生物，是氨基酸，核酸和脂质的一个碳原子的供体。Tetrahydrofolic acid 用作游离甲醛的受体，产生 5,10-亚甲基四氢叶酸-四氢叶酸。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

In Vitro: Tetrahydrofolic acid (0-200 ?M; 3 days; Adh5^-/- DT40 cells) exposure is cytotoxic to Adh5- and Fanconi anemia (FA)-deficient cells due to the accumulation of extensive DNA damage and chromosome breaks.
Tetrahydrofolic acid (0-100 ?M; 16 hours; Adh5^-/- DT40 cells) treatment strongly promots FANCD2 and ser139-H2AX focus formation in Adh5^-/- cells in a dose-dependent manner.
Tetrahydrofolic acid exposure activates the DNA damage response (DDR) due to uncontrolled activity of the thymidylate synthase enzyme, which causes a depletion of essential nucleotides, and promotes repair by a homologous recombination mechanism.

In Vivo: Tetrahydrofolic acid (62.5 mg/kg; intraperitoneal injection; daily; Adh5^-/- mice) treatment perturbs the hematopoiesis of hematopoietic cells, increases ser139-H2AX phosphorylation, and decreases the survival of progenitor cells (HSPCs) suggesting that excess Tetrahydrofolic acid could be mutagenic and genotoxic to bone marrow cells.

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