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GRGDSPK TFA

CAS No. :

MCE 站：GRGDSPK TFA

产品活性：GRGDSPK TFA (EMD 56574 TFA) 是包含精氨酸-甘氨酸-天冬氨酸 (RGD) 的多肽。 GRGDSPK TFA 是一种竞争性且可逆的抑制肽，可抑制整联蛋白-纤连蛋白结合。GRGDSPK TFA 可以用于研究整联蛋白在骨形成和吸收中的作用。

研究领域：Others

作用靶点：Others

In Vitro: GRGDSPK TFA (EMD 56574 TFA; RGD; 0.1-50 μM; for 4 days) inhibits mineralization in a dose-dependent manner as determined by measuring calcium content and 70 bonehnit area of tissue in parietal bones 18 days old isolated from pregnant Sprague-Dawley rats.
GRGDSPK TFA (10, 50 μM; for 4 days) dramatically alteres bone morphology, with a disruption of osteoblast and mineralized matrix organization.
GRGDSPK TFA (RGD; 250 μM), added to the medium, effectively blocks integrin-fibronectin binding and significantly increases the average size of wild-type cell aggregates.
When GRGDSPK TFA (250 μM) is added, wild-type mesendodermal progenitors exhibits strongly reduced adhesion forces and work, indicating that the detachment parameters recorded are specific for fibronectin and that integrins expressed in mesendodermal progenitors are involved.
GRGDSPK TFA (RGD-containing, 1.5 mM, 1.0 mM, and 0.5 mM) and RGD-mod-ified peptides impair the ability of sperm to fertilizebovine oocytes, illustrated by a reduction in cleavage in a dose-dependent manner.

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