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Dermaseptin TFA

CAS No. :

MCE 站：Dermaseptin TFA

产品活性：Dermaseptin TFA 是从青蛙皮肤中分离出来的一种肽，在微摩尔浓度下表现出对细菌、真菌和原生动物强有力的抗菌 (antimicrobial) 活性。

研究领域：Anti-infection

作用靶点：Bacterial  |  Fungal

In Vitro: Dermaseptin TFA is a water-soluble, thermostable, and nonhemolytic peptide endowed with highly potent antimicrobial activity against pathogenic fungi at micromolar concentration. Circular dichroism spectra of Dermaseptin TFA in hydrophobic media indicated 80% alpha-helical conformation, and predictions of secondary structure suggested that Dermaseptin TFA can be configured as an amphiphatic alpha-helix spanning over residues 1-27, a structure that perturbs membrane functions regulating water flux. Dermaseptin TFA exerts a lytic action upon bacteria, protozoa, yeasts, and filamentous fungi at micromolar concentrations. Molecular elements responsible for the exceptional antimicrobial potency of Dermaseptin TFA are to be traced to the NH2-terminal alpha-helical amphipathic segment spanning residues 1-18 of the molecule.
Dermaseptin TFA (5-100 μg/ml; 48 hours) inhibits by 100% the proliferation of most microorganisms tested, including Gram-positive or Gram-negative bacteria, parasites, yeasts, and filamentous fungi, at micromolar concentrations.
Dermaseptin TFA (5-100 μg/ml; 48 hours) does not inhibit the proliferation of human KJ3 cells after a 48 h incubation, and Dermaseptin TFA treatment for 1 h does not permeate guinea pig lymphocytes up to the highest concentration assayed (200 μg/ml). Hemolysis of rabbit erythrocytes occurrs after 1 h of treatment at doses above 200 μg/ml, with 50% hemolysis at 350 μg/ml.
Dermaseptin TFA has antimicrobial activities and is against Aeromonas cauiae, Pseudomonas aeroginusa, Escherichia coli, Enterococcus faecalis, L. mezicana (NF^α strain) and Microsporum canis (IP1194) with MIC values of 50 μg/ml; 100 μg/ml; 25 μg/ml; 15 μg/ml; and 50 μg/ml, respectively.

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