MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

MOTS-c(human) acetate

CAS No. :

MCE 站：MOTS-c(human) acetate

产品活性：MOTS-c(human) acetate 是一种线粒体衍生的肽，可诱导 AMP 类似物 AICAR 的积累，增加 AMPK 的激活及其下游 GLUT4 的表达。MOTS-c(human) acetate 可诱导葡萄糖摄取并改善胰岛素敏感性，对肥胖，糖尿病，运动和长寿的调节具有影响。

研究领域：Epigenetics  |  PI3K/Akt/mTOR  |  Membrane Transporter/Ion Channel

作用靶点：AMPK  |  GLUT

In Vitro: MOTS-c inhibits the folate cycle at the level of 5Me-THF, resulting in an accumulation of AICAR [5-aminoimidazole-4-carboxamide ribonucleotide). MOTS-c also increases cellular NAD⁺ levels, which are also nucleotide precursors.
MOTS-c is a mitochondrial signal that stimulates cellular glucose uptake while suppressing respiration. The glucose taken up in response to MOTS-c is routed to the anabolic pentose phosphate pathway (PPP), which provides carbon sources for the synthesis of purines, rather than being metabolized through glycolysis. In addition, MOTS-c increases the levels of carnitine shuttles, which transport activated fatty acids into the mitochon-dria for β-oxidation, increases the level of a β-oxidation intermediate, and reduces intracellular levels of essential and non-essential fatty acids, suggesting enhanced lipid utilization; myocytes that stably overexpress MOTS-c also exhibits increased glucose uptake.

In Vivo: MOTS-c injections in mice show activation of skeletal muscle AMPK and increased the level of its downstream glucose transporter GLUT4. MOTS-c may also act as a potential mitochondrial signal that mediates an exercise-induced mitohormesis response, thereby stimulating physiological adaptation and increased tolerance to exercise.
The primary target organ of MOTS-c appears to be skeletal muscle and fat. MOTS-c levels in mice decline with age in skeletal muscle and in circulation concomitantly with the age-dependent development of insulin resistance. Restoring MOTS-c levels by systemic injections in older mice (12 mo.) successfully reverses age-dependent skeletal muscle insulin resistance.

相关产品：Bioactive Compound Library Plus  |  Doxorubicin hydrochloride  |  Metformin hydrochloride  |  Dorsomorphin  |  AICAR  |  A-769662  |  BAY-876  |  GSK-690693  |  STO-609  |  Phenformin hydrochloride  |  [6]-Gingerol  |  Phloretin  |  WZ4003  |  Palmitelaidic Acid  |  STF-31  |  Urolithin B  |  GSK621  |  Flufenamic acid  |  Chitosan oligosaccharide  |  Amarogentin  |  7-Methoxyisoflavone  |  Buformin hydrochloride  |  Danthron  |  Ginkgolide C  |  ZLN024 hydrochloride  |  Ampkinone  |  EB-3D  |  Demethyleneberberine

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。