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Silibinin

CAS No. : 22888-70-6

MCE 站：Silibinin

产品活性：Silibinin (Silibinin A) 为抗癌和化疗预防化合物，能抑制细胞增殖和迁移。

研究领域：Autophagy  |  Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  NF-κB

作用靶点：Autophagy  |  Reactive Oxygen Species

In Vitro: Silibinin (Silybin) significantly induced the expression of the non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) in both p53 wild-type and p53-null cancer cell lines.
Silibinin (Silybin) induced cell death in human breast cancer cell lines MCF7 and MDA-MB-231.
Silibinin (Silybin) treatment resulted in a dose- and time-dependent inhibition of HCC cell viability.
Silibinin (Silybin) treatment decreased the expression of the Notch1 intracellular domain (NICD), RBP-Jκ, and Hes1 proteins, upregulated the apoptosis pathway-related protein Bax, and downregulated Bcl2, survivin, and cyclin D1.

In Vivo: Topical application of silibinin at the dose of 9 mg/mouse effectively suppressed oxidative stress and deregulated activation of inflammatory mediators and tumorigenesis.
The kidney cortex of vehicle-treated control OVE26 mice displayed greater Nox4 expression and twice as much superoxide production than cortex of silybin-treated mice. The glomeruli of control OVE26 mice displayed 35% podocyte drop out that was not present in the silybin-treated mice.

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