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L-Phenylalanine

CAS No. : 63-91-2

MCE 站：L-Phenylalanine

产品活性：L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) 是分离自大肠杆菌的必需氨基酸。L-Phenylalanine 是一种电压依赖性 α2δ 亚基 Ca2⁺ 通道拮抗剂，K_i 为 980 nM。L-Phenylalanine 是 NMDARs (K_B 573 μM) 和非 NMDARs 的甘氨酸和谷氨酸结合位点的竞争性拮抗剂。L-Phenylalanine 广泛用于食品香料和药品的生产中。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Metabolic Enzyme/Protease

作用靶点：Calcium Channel  |  iGluR  |  Endogenous Metabolite

In Vitro: DAHP synthetase (DS) and chorismate mutase/prephenate dehydratase (CM/PD) are key enzymes in the L-Phenylalanine biosynthesis pathway. DS is sensitive to feedback inhibition by tyrosine, and CM/PD is subject to feedback inhibition by L-Phenylalanine.L-Phenylalanine attenuates non-NMDA receptor function in cultured neurons with an IC₅₀ of 980 μM.

In Vivo: The effects of L-Phenylalanine on NMDA-activated currents (I_NMDA) are studied in cultured hippocampal neurons from newborn rats using the patch-clamp technique. L-Phenylalanine specifically and reversibly attenuates I_NMDA in a concentration-dependent manner (IC₅₀ of 1.71 mM). L-Phenylalanine inhibits specifically NMDAR current in hippocampal neurons by competing for the glycine-binding site.

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