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Sarafloxacin hydrochloride

CAS No. : 91296-87-6

MCE 站：Sarafloxacin hydrochloride

产品活性：Sarafloxacin (hydrochloride) (A-56620 (hydrochloride)) 是抗菌化合物。

研究领域：Anti-infection

作用靶点：Bacterial  |  Antibiotic

In Vitro: Sarafloxacin (hydrochloride) is a fluoroquinolone antibiotic registered for use against poultry diseases. Sarafloxacin treatment demonstrated mineralization to 14CO2 amounting to 0.58%, 0.49%, and 0.57% in loam, silt loam, and sandy loam soils, respectively, at the termination of the test. The inhibitory level of sarafloxacin for the tested bacteria was strain dependent. It appeared that in broth culture Escherichia coli isolates were sensitive to sarafloxacin concentrations 5-fold lower than the concentrations present in the simulated gut model, suggesting that sarafloxacin may be partially unavailable due to absorption to organic matter in the model.

In Vivo: Administering Sarafloxacin (hydrochloride) in the feed for 5 d at a dose of 10 or 12.5 mg/kg of fish proved efficacious in treating channel catfish infected with E. ictaluri in all three field trials. Average survival of the nonmedicated group was 43% in trial 1, 11°% in trial 2, and 59% in trial 3. Survival of the corresponding Sarafloxacin hydrochloride-medicated groups averaged 68, 48, and 73%. Antibiotic therapy with Sarafloxacin hydrochloride significantly (P < 0.05) improved survival in all trials.

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