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ATP disodium salt

CAS No. : 987-65-5

MCE 站：ATP disodium salt

产品活性：ATP disodium salt (Adenosine 5'-triphosphate disodium salt) 是体内能量储存和代谢的重要物质，为代谢提供能量，同时在细胞中作为辅酶发挥作用。ATP disodium salt 是免疫和炎症中重要的内源性信号分子。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

In Vitro: ATP disodium salt (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs.
ATP disodium salt (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner.
ATP disodium salt stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis.

In Vivo: ATP disodium salt (50 mg/kg; i.p.) protects mice against bacterial infection in vivo.
ATP disodium salt induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo.

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