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Duloxetine

CAS No. : 116539-59-4

MCE 站：Duloxetine

产品活性：Duloxetine ((S)-Duloxetine) 是 5 羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂，K_i 为 4.6 nM，可作用于广泛性焦虑症。

研究领域：Neuronal Signaling

作用靶点：Serotonin Transporter

In Vitro: Duloxetine ((S)-Duloxetine) inhibits the reuptake of serotonin and norepinephrine in the central nervous system. Duloxetine is also considered a less potent inhibitor of dopamine reuptake. However, duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors and can therefore be considered to be a selective reuptake inhibitor at the 5-HT and NA transporters. Duloxetine undergoes extensive metabolism, but the major circulating metabolites do not contribute significantly to the pharmacologic activity. Major depressive disorder is believed to be due in part to an increase in pro-inflammatory cytokines within the central nervous system. Antidepressants including ones with a similar mechanism of action as duloxetine, i.e. serotonin metabolism inhibition, cause a decrease in proinflammatory cytokine activity and an increase in anti-inflammatory cytokines; this mechanism may apply to duloxetine in its effect on depression but research on cytokines specific to duloxetine therapy is lacking.
The analgesic properties of duloxetine in the treatment of diabetic neuropathy and central pain syndromes such as fibromyalgia are believed to be due to sodium ion channel blockade.

相关产品：Paroxetine hydrochloride  |  Fluvoxamine maleate  |  Imipramine hydrochloride  |  Sertraline hydrochloride  |  Desipramine hydrochloride  |  Duloxetine hydrochloride  |  Amitriptyline hydrochloride  |  Escitalopram oxalate  |  Clomipramine hydrochloride  |  Citalopram hydrobromide  |  Vilazodone  |  Dapoxetine hydrochloride  |  Venlafaxine hydrochloride  |  Milnacipran hydrochloride  |  Amitifadine hydrochloride  |  Azaphen dihydrochloride monohydrate  |  Cinchonidine  |  (S)-Venlafaxine

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