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Methylene Blue

CAS No. : 61-73-4

MCE 站：Methylene Blue

产品活性：Methylene blue (Basic Blue 9) 是一种鸟苷酸环化酶 (sGC)，单胺氧化酶 A (MAO-A) 和 NO 合酶 (NOS) 抑制剂。Methylene blue 是一种血管加压剂，在医疗中通常用作染料。Methylene blue 具有抗伤害感受，抗疟疾，抗抑郁和抗焦虑作用，可用于高铁血红蛋白血症，神经退行性疾病和异环磷酰胺引起的脑病的研究。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation  |  Anti-infection

作用靶点：Guanylate Cyclase  |  Monoamine Oxidase  |  NO Synthase  |  Parasite

In Vitro: By acting as an alternative electron acceptor/donor Methylene blue restores mitochondrial function, improves neuronal energy production and inhibits the formation of superoxide.
Methylene blue inhibits cytochrome P450 (CYP) isozymes. Methylene blue is an odorless, water soluble, dark blue-green crystalline powder, which turns blue whenever mixed in solution. Methylene blue is a vasopressor that impacts the NO synthetic pathway by inhibiting inducible NOS and inhibiting the subsequent activation of sGC. In addition, by binding to the iron heme moiety of sGC and causing enzyme inhibition, Methylene blue blocks accumulation of cyclic GMP (cGMP), competing directly with NO in its ability to activate soluble guanylyl cyclase.

In Vivo: Methylene Blue (1, 5, and 25 μg/rat) significantly decreases sevoflurane minimum alveolar anesthetic concentration (MAC) and brain cyclic guanosine monophosphate (cGMP) content in a dose-dependent manner in male Sprague-Dawley rats (7-week-old, 200-250 g).
Methylene blue is used as a dye in chromoendoscopy, and is sprayed onto the mucosa of the gastrointestinal tract in order to identify dysplasia, or pre-cancerous lesions.
Methylene blue is able to restore vascular tone, normalize mean arterial pressures (MAP), and reduce vasopressor usage.

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