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Gap 26 TFA

CAS No. :

MCE 站：Gap 26 TFA

产品活性：Gap 26 TFA 是一种连接蛋白 (connexin) 模拟肽，由连接蛋白 connexin 43 (gap junction 阻滞剂)个胞外环的第 63-75 残基组成，包含SHVR氨基酸基序。

研究领域：Cytoskeleton

作用靶点：Gap Junction Protein

In Vitro: Gap 26 (0.25 mg/mL, 30 min) reduces the wave size in the three cell lines (RBE4, SV-ARBEC and ECV304). Gap 26 (0.25 mg/mL, 30 min) completely abolishes the InsP3-triggered ATP response and reduced the ATP release to below the control level, indicating that the basal ATP release is also affected.
Gap 26 does indeed significantly inhibit our InsP3-triggered intercellular calcium waves, but it did not have any effect on dye coupling through junctional channels as evidenced by the FRAP experiments, despite the fact that connexin 43 was present in the cell lines used.
Gap 26 (100-300 μM) dose-dependently reduces the rhythmic responses of rabbit superior mesenteric arteries, with IC₅₀ of 28.4 ± 3.4 μM.

相关产品：Bioactive Compound Library Plus  |  Meclofenamic acid sodium  |  Larazotide acetate  |  Tonabersat  |  Carbenoxolone disodium  |  Gap 27  |  Gap 26

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