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21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione

CAS No. : 37413-91-5

MCE 站：21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione

产品活性：21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione 是 delta 9,11 类固醇类合成的中间体 (intermediate)，如 Vamorolone?(HY-109017)。delta 9,11 steroids 是糖皮质激素的修饰后的产物，具有抗炎 (anti-inflammatory) 特性。delta 9,11 类固醇类可以用作保护细胞损伤(脂质过氧化)和抑制新生血管的试剂。

研究领域：GPCR/G Protein  |  NF-κB

作用靶点：Glucocorticoid Receptor  |  NF-κB

In Vitro: Δ9,11 derivatives are designed and developed to stably incorporate into cell membranes and inhibit lipid peroxidation without glucocorticoid or mineralocorticoid activities, thus avoiding side effects associated with traditional corticosteroids.
VBP15 acts as a lead compound due to potent NF-κB inhibition and GR translocation similar to prednisone and dexamethasone, lack of transactivation properties, and good bioavailability.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Immunology/Inflammation Compound Library  |  NF-κB Signaling Compound Library  |  Stem Cell Signaling Compound Library  |  Natural Product Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Differentiation Inducing Compound Library  |  Oxygen Sensing Compound Library  |  Ferroptosis Compound Library  |  Pyroptosis Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Dexamethasone  |  Bortezomib  |  Hydrocortisone  |  Pyrrolidinedithiocarbamate ammonium  |  Mifepristone  |  JSH-23  |  Shikonin  |  Triptolide  |  Rocaglamide  |  Dihydroartemisinin  |  Corticosterone  |  Baicalin  |  BAY 11-7085  |  Sulfasalazine  |  Betulinic acid  |  SN50  |  Parthenolide  |  Medroxyprogesterone acetate  |  (-)-DHMEQ  |  Methylprednisolone  |  Prednisone  |  5-Aminosalicylic Acid  |  Caffeic acid phenethyl ester  |  Neferine  |  Budesonide  |  Prednisolone  |  Tomatidine  |  QNZ  |  Withaferin A

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