MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Schisandrol B

CAS No. : 58546-54-6

MCE 站：Schisandrol B

产品活性：Schisandrol B (Gomisin-A) 是 Schisandra sphenanthera 的主要活性成分，具有保肝作用。Schisandrol B 抑制活性氧 (ROS) 的产生。Schisandrol B 抑制 P-糖蛋白和 CYP3A 的活性，还具有抗炎，抗糖尿病和抗氧化的作用。

研究领域：Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  NF-κB  |  Autophagy

作用靶点：Reactive Oxygen Species  |  Cytochrome P450  |  Autophagy

In Vitro: Schisandrol B (Gomisin-A; 1-10 μM; 2 days) treatment decreases the aging related inflammatory molecules, such as, COX-2, IL1β, and TNF-α. Schisandrol B attenuates the activity of senescence-associated β-galactosidase.
Schisandrol B (Gomisin-A; 1-10 μM; 2 days) inhibits reactive oxygen species production even in the stress-induced premature senescence (SIPS)-human diploid fibroblast (HDF) cells.
Schisandrol B (Gomisin-A; 1-10 μM) inhibits the MAPK pathway and the translocation of NF-κB to the nucleus.
Schisandrol B (Gomisin-A; 1-10 μM) promotes the autophagy and mitochondrial biogenesis factors through the translocation of Nrf-2, and inhibits aging progression in the SIPS-HDF cells.
Schisandrol B (0-80?μM) dramatically alters APAP metabolic activation by inhibiting the activities of CYP2E1 and CYP3A11.

In Vivo: Schisandrol B (12.5?-200?mg/kg; oral administration; seven times with an interval of 12?hours) pretreatment significantly attenuates the increases in alanine aminotransferase and aspartate aminotransferase activity, and prevents elevated hepatic malondialdehyde formation and the depletion of GSH in a dose-dependent manner. Schisandrol B abrogates APAP-induced activation of p53 and p21, and increases expression of liver regeneration and antiapoptotic-related proteins such as cyclin D1 (CCND1), PCNA, and BCL-2.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Metabolism/Protease Compound Library  |  NF-κB Signaling Compound Library  |  Stem Cell Signaling Compound Library  |  Natural Product Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Reprogramming Compound Library  |  Diabetes Related Compound Library  |  Oxygen Sensing Compound Library  |  Ferroptosis Compound Library  |  Medicine Food Homology Compound Library  |  Pyroptosis Compound Library  |  Orally Active Compound Library  |  Traditional Chinese Medicine Monomer Library  |  Acetylcysteine  |  H2DCFDA  |  Quercetin  |  Mitoquinone mesylate  |  (-)-Epigallocatechin Gallate  |  L-Ascorbic acid  |  Diphenyleneiodonium chloride  |  Mito-TEMPO  |  Verapamil hydrochloride  |  GSK2795039  |  Trolox  |  Apigenin  |  L-Glutathione reduced  |  Dimethyl fumarate  |  Fenofibrate  |  Berberine chloride  |  Zinc Protoporphyrin  |  Sodium dichloroacetate  |  Lycopene  |  2-Methoxyestradiol  |  TPEN  |  Urolithin A  |  Ketoconazole  |  α-Vitamin E  |  1-Aminobenzotriazole  |  Itraconazole  |  Tempol  |  Piperlongumine  |  Abiraterone  |  Coenzyme Q10

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。