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(E)-3,4-Dimethoxycinnamic acid

CAS No. : 14737-89-4

MCE 站：(E)-3,4-Dimethoxycinnamic acid

产品活性：(E)-3,4-Dimethoxycinnamic acid 是 3,4-Dimethoxycinnamic acid 的低活性异构体。3,4-Dimethoxycinnamic acid 通过 ROS 介导的信号途径对 L-02 细胞发挥抗凋亡作用。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：Reactive Oxygen Species  |  Virus Protease

In Vitro: 3,4-Dimethoxycinnamic acid (Methyl ferulic acid; 25, 50 and 100 ?M) attenuates the ethanol-induced apoptosis of ethanolexposed L-02 cells.
3,4-Dimethoxycinnamic acid (25, 50 and 100 ?M) inhibits the expression levels of Nox4 and p22^phox in L-02 cells.
3,4-Dimethoxycinnamic acid (25, 50 and 100 ?M) treatment attenuates ethanol-induced MAPK phosphorylation in L-02 cells.
3,4-Dimethoxycinnamic acid decreases the expression levels of superoxide dismutase, catalase and phospholipid hydroperoxide gluthione peroxidase, and downregulates the levels of Bax/Bcl-2 and the cleaved forms of caspase-3 in a dose- and time-dependent manner.

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