MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Ginsenoside Rb3

CAS No. : 68406-26-8

MCE 站：Ginsenoside Rb3

产品活性：Ginsenoside Rb3 是从 Panax notoginseng 中提取的。在 293T 细胞系中 Ginsenoside Rb3 抑制 TNFα 诱导的 NF-κB 转录活性，IC₅₀ 为 8.2 μM。Ginsenoside Rb3 还抑制 COX-2 和 iNOS mRNA的诱导。

研究领域：NF-κB  |  Immunology/Inflammation

作用靶点：NF-κB  |  COX  |  NO Synthase

In Vitro: Ginsenoside Rb3 (0.1-10 μM) is tested for inhibition of tumor necrosis factor-α (TNF)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) luciferase reporter activity using a human kidney 293T cell-based assay. Ginsenoside Rb3 shows the significant activity with an IC₅₀ of 8.2 μM. Ginsenoside Rb3 also inhibits the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells have been treated with TNF-α (10 ng/mL). Ginsenoside Rb3 (0.1-10 μM) significantly increases cell viability and inhibits lactate dehydrogenase (LDH) release in a dose-dependent manner. PC12 cell viability as determined by MTT reduction is also markedly decreased after the cell is exposed to oxygen and glucose deprivation (OGD)/OGD-Rep. But, when the cells are pretreated with Ginsenoside Rb3 (0.1, 1, and 10 μM), OGD/OGD-Rep induced cell toxicity is significantly attenuated, which is concentration-dependently attenuated by Ginsenoside Rb3 treatment. The viabilities are raised to 52.8%±5.6%, 64.6%±5.7%, and 76.4%±8.8%, respectively, compared with the control group.

In Vivo: Ginsenosides Rb3 is a major compound isolated from Gynostemma pentaphyllum that holistically improves gut microenvironment and induces anti-polyposis in Apc^Min/+ mice. Six-weeks-old mice are subjected to Rb3 treatment, before the appearance of the intestinal polyps. All the mice are monitored for food intake, water consumption, and weight changes. Throughout the experiment, no Rb3/Rd-associated weight loss in mice is observed. In addition, none of the treated mice show variations in food and water consumption. Whereas, the number and size of the polyps are effectively reduced by Rb3 treatments.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  NF-κB Signaling Compound Library  |  Stem Cell Signaling Compound Library  |  Natural Product Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Differentiation Inducing Compound Library  |  Oxygen Sensing Compound Library  |  Medicine Food Homology Compound Library  |  Terpenoids Library  |  Pyroptosis Compound Library  |  Traditional Chinese Medicine Monomer Library  |  Neuroprotective Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Bortezomib  |  Pyrrolidinedithiocarbamate ammonium  |  Acetaminophen  |  Mifepristone  |  JSH-23  |  Indomethacin  |  L-NAME hydrochloride  |  Shikonin  |  Celecoxib  |  Aspirin  |  Triptolide  |  Rocaglamide  |  Dihydroartemisinin  |  Baicalin  |  BAY 11-7085  |  Sulfasalazine  |  Betulinic acid  |  SN50  |  Parthenolide  |  (-)-DHMEQ  |  Ibuprofen  |  5-Aminosalicylic Acid  |  L-NMMA acetate  |  1400W Dihydrochloride  |  Caffeic acid phenethyl ester  |  Neferine  |  Tomatidine  |  QNZ  |  Withaferin A  |  Catechin

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。