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L-Chicoric Acid

CAS No. : 70831-56-0

MCE 站：L-Chicoric Acid

产品活性：L-Chicoric Acid ((-)-Chicoric acid) 是一种二咖啡酰酒石酸，是一种有效的，选择性的和可逆的 HIV-1 整合酶 (HIV-1 integrase) 抑制剂，IC₅₀ 约为 100 nM。L-Chicoric Acid 还可抑制组织培养物中的 HIV-1 的复制。

研究领域：Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：HIV Integrase  |  HIV

In Vitro: L-Chicoric Acid inhibits integration at concentrations from 500 nM to 10 μM but also inhibits entry at concentrations above 1 μM. L-Chicoric Acid clearly affects viral entry at concentrations of 5 μM and higher. L-Chicoric Acid also inhibits integration as indicated both by an increased ratio of two LTR circle DNA to cDNA and an accompanying decrease in integrated provirus. The EC₅₀ of L-Chicoric Acid against HIV is approximately 500 nM, a concentration that does not inhibit HIV entry in H9 cells.
The ED₅₀ of L-Chicoric Acid against HIV_NL4-3 control virus is 400 nM, while HIV_NL4-3 passaged in the presence of 8 μM L-Chicoric Acid is completely resistant to the compound.

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