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Notoginsenoside R1

CAS No. : 80418-24-2

MCE 站：Notoginsenoside R1

产品活性：Notoginsenoside R1 (Sanchinoside R1)，是一种从 P. notoginseng 中分离出来的皂苷。 Notoginsenoside R1 具有抗氧化，抗炎，抗血管生成和抗凋亡的活性。Notoginsenoside R1 可提供抗缺血/再灌注 (I/R) 损伤的心脏保护作用。Notoginsenoside R1 还可以提供神经保护作用。

研究领域：Neuronal Signaling  |  Apoptosis

作用靶点：Amyloid-β  |  Apoptosis

In Vitro: Notoginsenoside R1 (2.5-80 μM; 24 h) inhibits the hypoxia-reoxygenation (H/R)-induced cell death, intracellular ROS accumulation, and mitochondrial membrane depolarization in H9c2 cardiomyocytes.
Notoginsenoside R1 (5-20 μM; 24 h) inhibits the H/R-induced H9c2 cardiomyocytes apoptosis in a concentration-dependent manner.
Notoginsenoside R1 (1-100 μM; 24 h) dose-dependently protects PC12 cells and primary neurons from Aβ-induced cell death and apoptosis.
Notoginsenoside R1 (10 μM; 24 h) inhibits Aβ_25-35-induced ROS production, mitochondrial damage and MAPK activation in PC12 cells.

In Vivo: Notoginsenoside R1 (5 mg/kg/h; infused via the right jugular vein) increases red blood cell velocity, reduces the number of adherent leukocytes and inhibits mast cell degranulation and cytokine elevation in rats.

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