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L-Ascorbic acid sodium salt

CAS No. : 134-03-2

MCE 站：L-Ascorbic acid sodium salt

产品活性：L-Ascorbic acid sodium salt (Sodium L-ascorbate)，一种电子供体，是一种内源性抗氧化剂。L-Ascorbic acid sodium salt 选择性抑制 Ca_v3.2 通道 (Ca_v3.2 channels)，IC₅₀ 为 6.5 μM。L-Ascorbic acid sodium salt 还是一种胶原沉积促进剂和弹性生成抑制剂。

研究领域：Neuronal Signaling  |  Membrane Transporter/Ion Channel  |  Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Calcium Channel  |  Reactive Oxygen Species  |  Apoptosis

In Vitro: The conditioned?medium?for?B16F10?cells significantly inhibits?cell?apoptosis?induced by?L-Ascorbic acid sodium salt (Sodium?L-ascorbate) (10 mM), and the effective ingredients in the?medium?show a relative molecular mass below 5,000.

In Vivo: Tg rats treated with L-Ascorbic acid sodium salt (Sodium?L-ascorbate) show a higher incidence of carcinoma (29.6%), compared to those without L-Ascorbic acid sodium salt (15.4%). Independent of the L-Ascorbic acid sodium salt treatment, transgenic rats exhibit various kinds of malignant tumors in various organs.
After 12 weeks of PEITC-treatment, both simple hyperplasia and papillary or nodular (PN) hyperplasia have developed in all animals, but the majority of these lesions have disappeared at week 48, irrespective of the L-Ascorbic acid sodium salt-treatment. The same lesions after 24 weeks of PEITC-treatment have progressed to dysplasia and carcinoma, in a small number of cases by week 48, but enhancement by the L-Ascorbic acid sodium salt-treatment is evident only with simple hyperplasias and PN hyperplasias in rats.

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