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Diosmetin

CAS No. : 520-34-3

MCE 站：Diosmetin

产品活性：Diosmetin是抑制人CYP1A酶活性的天然类黄酮, 在HepG2细胞的 IC₅₀值为40 μM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Cytochrome P450

In Vitro: Diosmetin inhibits cell proliferation in HepG2 cells in a concentration-dependent manner. Untreated HepG2 cells grow well and are observed to have with normal skeletons, whereas cells treated with diosmetin are distorted and a number of them become round and floating.

In Vivo: Pretreatment with diosmetin significantly reduces serum levels of amylase and lipase; the histological injury; the secretion of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6; myeloperoxidase (MPO) activity, trypsinogen activation peptide (TAP) level, the expression of inducible nitric oxide synthase (iNOS); and the nuclear factor (NF)-κB activation in cerulein-induced acute pancreatitis.

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