MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

1,3-Dicaffeoylquinic acid

CAS No. : 19870-46-3

MCE 站：1,3-Dicaffeoylquinic acid

产品活性：1,3-Dicaffeoylquinic acid是咖啡酰奎宁酸衍生物，具有抗氧化活性和自由基清除活性。

研究领域：PI3K/Akt/mTOR  |  Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  NF-κB

作用靶点：PI3K  |  Akt  |  Reactive Oxygen Species

In Vitro: 1,3-Dicaffeoylquinic acid shows increased neuronal cell viability against Aβ(42) toxicity in a concentration-dependent manner in neurons. 1,3-Dicaffeoylquinic acid activates both phosphoinositide 3-kinase (PI3K)/Akt and extracellular regulated protein kinase 1/2 (Erk1/2) with stimulating their upstream tyrosine kinase A (Trk A). 1,3-Dicaffeoylquinic acid's anti-apoptotic potential is related to the enhanced inactivating phosphorylation of glycogen synthase kinase 3β (GSK3β) and the modulation of expression of apoptosis-related protein Bcl-2/Bax. 1,3-Dicaffeoylquinic acid (10 μM, 20 μM, 50 μM, and 100 μM) significantly increases cell viablity before OGD/reperfusion, and prevents the depletion of GSH under OGD/reperfusion insult. 1,3-Dicaffeoylquinic acid induces nuclear translocation of Nrf2 in OGD/reperfusion treated astrocytes, and induces increased GCL activity, and the effect is lost in Nrf2 siRNA-transfected cells.

In Vivo: 1,3-Dicaffeoylquinic acid (32.0 mg/kg, p.o.) and 1-O-ABL are absorbed very quickly in Wistar rats. The maximum plasma concentrations for 1,3-Dicaffeoylquinic acid and 1-O-ABL are 44.5 ± 7.1 and 19.1 ± 6.9 ng/mL, respectively.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  Metabolism/Protease Compound Library  |  NF-κB Signaling Compound Library  |  PI3K/Akt/mTOR Compound Library  |  Stem Cell Signaling Compound Library  |  Natural Product Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Ferroptosis Compound Library  |  Glycolysis Compound Library  |  Pyroptosis Compound Library  |  Cytoskeleton Compound Library  |  Glutamine Metabolism Compound Library  |  Neuroprotective Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  3-Methyladenine  |  LY294002  |  Acetylcysteine  |  H2DCFDA  |  Wortmannin  |  Quercetin  |  Mitoquinone mesylate  |  740 Y-P  |  (-)-Epigallocatechin Gallate  |  L-Ascorbic acid  |  Diphenyleneiodonium chloride  |  Mito-TEMPO  |  GSK2795039  |  Honokiol  |  Trolox  |  L-Glutathione reduced  |  Dimethyl fumarate  |  Berberine chloride  |  GSK-690693  |  Zinc Protoporphyrin  |  Sodium dichloroacetate  |  Lycopene  |  2-Methoxyestradiol  |  TPEN  |  Urolithin A  |  α-Vitamin E  |  Artemisinin  |  Tempol  |  Piperlongumine  |  Coenzyme Q10

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。