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Coenzyme Q9

CAS No. : 303-97-9

MCE 站：Coenzyme Q9

产品活性：Coenzyme Q9 (Ubiquinone Q9) 是啮齿类动物泛醌的主要形式，是电子传递链中的一种双亲分子组分，具有内源性抗氧化剂的作用。Coenzyme Q9 可减轻糖尿病引起的抗氧化防御机制的下降。Coenzyme Q9 改善左心室功能，减少心肌梗死面积和心肌细胞凋亡。

研究领域：Apoptosis  |  Metabolic Enzyme/Protease

作用靶点：Apoptosis  |  Endogenous Metabolite

In Vivo: Coenzyme Q9 (5 mg/kg; p.o.; once a day for 4 weeks) reduces myocardial ischemia/reperfusion injury.
CoQ₁₀ and CoQ₉ are components of themitochondrial respiratory chain in mammals and can regulate some mitochondrial proteins/functions. Soybean, corn, and rapeseed oils are very rich sources of CoQ₁₀, whereas CoQ₉ has been found in high concentrations in corn oil.
The lack of a functional CoQ₉ protein in homozygous CoQ₉ mutant (CoQ₉(X/X)) mice causes a severe reduction in the CoQ₇ protein and a widespread CoQ deficiency and accumulation of demethoxyubiquinone. The deficit in CoQ induces a brain-specific impairment of mitochondrial bioenergetics performance, a reduction in respiratory control ratio, ATP levels and ATP/ADP ratio and specific loss of respiratory complex I. These effects lead to neuronal death and demyelinization with severe vacuolization and astrogliosis in the brain of CoQ₉ (X/X) mice that consequently die between 3 and 6 months of age.

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