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产品价格:电议      采购度:1593      原产地:美洲
发布时间:2021/7/21 17:36:13 所属地区:上海 上海市
简要描述:
(±)-Carnitine chloride 有D和L两种异构体。L-carnitine在脂肪酸的β-氧化中起重要作用,也具有抗氧化作用和抗炎活性。
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CAS No. : 461-05-2
MCE 站:(±)-Carnitine chloride
产品活性:(±)-Carnitine chloride 有D和L两种异构体。L-carnitine在脂肪酸的β-氧化中起重要作用,也具有抗氧化作用和抗炎活性。
研究领域:Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease
In Vitro: The main role of L-carnitine is to shuttle long-chain fatty acids across the inner mitochondrial membrane. After L-carnitine and acyl-CoA become acyl-carnitine by activation of carnitine palmitoyl transferase (CPT)-I, the transported acyl-carnitine is changed into acyl-CoA by CPT-II in the mitochondria matrix. Palmitoyl-CoA-induced mitochondrial respiration is increased by L-carnitine treatment, and then is accelerated by the presence of ADP. This acceleration is induced by treatment with L-carnitine in a concentration-dependent manner, and is saturated at 5 mM L-carnitine. Pretreatment with L-carnitine augments Nrf2 nuclear translocation, DNA binding activity and heme oxygenase-1 (HO-1) expression in H2O2-treated HL7702 cells. L-carnitine protects HL7702 cells against H2O2-induced cell damage through Akt-mediated activation of Nrf2 signaling pathway.
In Vivo: L-carnitine is found to down-regulate the ubiquitin proteasome pathway and increase IGF-1 concentrations in animal models. L-carnitine administration for 2 weeks of hindlimb suspension alleviates the decrease in weight and fiber size in the soleus muscle. In addition, L-carnitine suppresses atrogin-1 mRNA expression, which has been reported to play a pivotal role in muscle atrophy. Simultaneous treatment with L-carnitine attenuates the renal fibrosis (which correlated with a reduction of plasma TGF-β1 levels) and the pro-oxidative and proinflammatory status reported in L-NAME groups, with a concomitant increase in the expression of PPAR-γ.
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更新时间:2024/1/2 10:14:03
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