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Neuromedin B

CAS No. : 87096-84-2

MCE 站：Neuromedin B

产品活性：Neuromedin B 是一种含10个氨基酸的神经肽，属于蛙肽家族，为铃蟾肽相关肽。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

In Vitro: Potency to stimulate contraction of rat uterine smooth muscle, that is used as bioassay for isolation of Neuromedin B (NMB), is compared with Bombesin (BN). The relative potency, calculated on molar basis by taking BN as 100, is 48% for GRP and 4.9% for NMB. NMB also has contractile activity on rat stomach strip, but the potency (ratio of peptide concentration required to elicit 50% maximum response; EC₅₀) is only 5% of BN (EC₅₀ of BN/EC₅₀ of NMB) and about 10% of GRP (EC₅₀ of GRP/ EC₅₀ of NMB).

In Vivo: Potencies of NMB and GRP for smooth muscle contraction of fundus in wild-type and NMB-R-deficient mice with ED₅₀ of 14.4±2.3 (n=8) and 10.9±2.3 (n=8) in wild-type mice and NMB-R-deficient mice, respectively.

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