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Octreotide

CAS No. : 83150-76-9

MCE 站：Octreotide

产品活性：Octreotide 是一种生长抑素类似物，能够与 somatostatin 受体结合，主要有 2，3，5 亚型，可增强 Gi 活性，降低胞内 cAMP 的产生。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Somatostatin Receptor

In Vitro: Octreotide reverses the PA-induced alterations in Akt and GSK3β phosphorylation and expression of GS mRNA in HepG2 cells.

In Vivo: Octreotide significantly lowers the plasma glucose levels in the obese rats of the HFD group. Octreotide intervention significantly decreases the serum insulin concentration; however, there is no marked reduction in serum TG, TC, FFA, ALT and AST levels. Octreotide significantly inhibits the HOMA index. Octreotide decreases ipGTT and ipITT AUCs, but not significantly. Octreotide improves fat degeneration in rats with HFD-induced obesity and lipid droplet accumulation in PA-treated HepG2 cells. Octreotide promotes the phosphorylation of Akt and GSK3β and the expression of GS mRNA in rats with HFD-induced obesity. Octreotide reduces body weight and wet kidney weight compared with the vehicle-treated (CONT) group. PAS and Octreotide/PAS treatment decrease cAMP levels, but Octreotide alone does not in PCK rats. In the Octreotide/PAS group, there are a significantly fewer pS6-positive cells than in the PAS alone group.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  Bioactive Compound Library Plus  |  Peptidomimetic Library  |  Octreotide acetate  |  Pasireotide ditrifluoroacetate  |  MK-4256  |  CYN 154806 TFA  |  Cortistatin-14 TFA  |  L-803087  |  J-2156 TFA  |  CH 275  |  BIM-23056  |  Cyclosomatostatin  |  [Tyr1]-Somatostatin-14  |  SSTR5 antagonist 2

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