MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

L-Histidine

CAS No. : 71-00-1

MCE 站：L-Histidine

产品活性：L-Histidine 是婴儿必需的氨基酸。L-Histidine 是线粒体谷氨酰胺转运的抑制剂。

研究领域：Metabolic Enzyme/Protease

作用靶点：Mitochondrial Metabolism  |  Endogenous Metabolite

In Vitro: L-histidine completely inhibits growth and its effect on viability is inversely related to FLO11 expression. L-histidine does not affect the viability of the Δflo11 and S288c strains. L-histidine dramatically decreases air-liquid biofilm formation and adhesion to polystyrene of the flor yeasts with no effect on the transcription level of the FLO11 gene. Moreover, L-histidine modifies the chitin and glycans content on the cell-wall of flor yeasts.

In Vivo: L-histidine (100 mg/kg) completely inhibits the brain edema in thioacetamide-treated rats. Histamine release stimulated by high K⁺ from the hypothalamus in the L-histidine diet group is 60% of that in the control group. However, the concentrations of other monoamines and their metabolites are not changed by the L-histidine diet. The open-field tests show that the L-histidine diet group spends a shorter amount of time in the central zone, and the light/dark box tests demonstrate that the L-histidine diet group spends a shorter amount of time in the light box, suggesting that the L-histidine diet induced anxiety-like behaviors.

相关产品：Natural Product Library Plus  |  Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Metabolism/Protease Compound Library  |  Stem Cell Signaling Compound Library  |  Natural Product Library  |  FDA-Approved Drug Library  |  Human Endogenous Metabolite Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Reprogramming Compound Library  |  Anti-COVID-19 Compound Library  |  NMPA-Approved Drug Library  |  Orally Active Compound Library  |  Glutamine Metabolism Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Alkaloids Library  |  Rapamycin  |  3-Methyladenine  |  Acetylcysteine  |  5-Fluorouracil  |  ATP  |  CCCP  |  Retinoic acid  |  Hydrocortisone  |  Rotenone  |  Docetaxel  |  Estradiol  |  FCCP  |  Melatonin  |  Nicotinamide  |  Cytarabine  |  Isoprenaline hydrochloride  |  Prostaglandin E2  |  Acetaminophen  |  (-)-Epigallocatechin Gallate  |  β-Nicotinamide mononucleotide  |  Calcitriol  |  Mito-TEMPO  |  DHEA  |  Liothyronine  |  UK-5099  |  NAD+  |  Luteolin  |  Thymidine  |  Docosahexaenoic Acid  |  Kaempferol

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。