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O-Phospho-L-serine

CAS No. : 407-41-0

MCE 站：O-Phospho-L-serine

产品活性：O-Phospho-L-serine 是 L-serine 合成过程中的直接前体物质，是第三组 mGluR (mGluR4，mGluR6，mGluR7 和 mGluR8) 的激动剂，O-Phospho-L-serine 同时为 mGluR1 和 mGluR2 的拮抗剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Metabolic Enzyme/Protease

作用靶点：mGluR  |  Endogenous Metabolite

In Vitro: O-Phospho-L-serine (l-SOP) weakly binds to mGluR1, and antagonizes the effects of l-glutamate. l-SOP activates the group III receptors (mGluR4, mGluR6, mGluR7, and mGluR8), but mGluR7 has much lower affinity for l-SOP than the other group III receptors and also displays lower efficacy for both ligands. O-Phospho-L-serine (l-SOP) generates enhanced intracellular calcium responses in mGluR4 transfected cells. l-SOP inhibits the l-glutamate mediated mGluR1 response, with a K_i of 1 mM; l-SOP displays a substantially more potent inhibition of mGluR2 activation, with a K_i of 1 μM, three orders-of-magnitude more potent than for mGluR1. l-SOP induces membrane potential changes in HEK/TRPC4 cells transfected with mGluR4 or mGluR6. l-SOP induces TRPC4β activation mediated by Gα_i/o proteins. O-Phospho-L-serine (L-SOP) inhibits Müller glia proliferation, without affecting light-induced photoreceptor cell death. L-SOP disrupts Müller glia proliferation subsequent to or in parallel with the activation of ascl1a and stat3 expression in the light-damaged retina. L-SOP inhibits cone cell regeneration in the light-damaged retina.

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