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Robenidine hydrochloride

CAS No. : 25875-50-7

MCE 站：Robenidine hydrochloride

产品活性：Robenidine hydrochloride 是一种抗球虫药, 对 MRSA 和 VRE 也有抑制活性，其 MIC₅₀ 值分别为 8.1 和 4.7 μM。

研究领域：Anti-infection

作用靶点：Bacterial  |  Parasite

In Vitro: Robenidine (compound 1) inhibits the growth of MRSA and VRE with MIC values of 8.1 and 4.7 μM, respectively. Robenidine is bactericidal against all of the S. aureus strains tested with MBC/MIC₉₀ ratios ≤2. A profound and negative impact on the MIC values with a 4-fold decrease with Robenidine at 2% serum and no activity at 50% serum is observed.

In Vivo: The time that the mean plasma concentration exceeds the concentration of 1 ?g/mL is approximately 6 h in the Florfenicol (FFC) alone group; however, it is lowered to 4 h by Robenidine (ROB) pretreatment. The terminal elimination half-life (t_1/2z), area under the concentration-time curve (AUC), area under the first moment curve (AUMC), and mean residence time (MRT) significantly decreased, whereas the elimination rate constant (λ_z) and total body clearance (CL_z) obviously increased in rabbits pretreated with Robenidine.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Natural Product Library  |  Antibacterial Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Puromycin dihydrochloride  |  Chloroquine  |  Staurosporine  |  Dexamethasone  |  Doxycycline (hyclate)  |  Actinomycin D  |  G-418 disulfate  |  5-Azacytidine  |  Etoposide  |  Mitomycin C  |  CCCP  |  Nigericin sodium salt  |  Resveratrol  |  Tunicamycin  |  Hygromycin B  |  Hydroxychloroquine sulfate  |  Tacrolimus  |  Ionomycin  |  Vancomycin hydrochloride  |  Streptozocin  |  Tanespimycin  |  Anisomycin  |  Neomycin sulfate  |  Ampicillin sodium  |  Ivermectin  |  Geldanamycin  |  Kaempferol

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