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Quinidine hydrochloride monohydrate

CAS No. : 6151-40-2

MCE 站：Quinidine hydrochloride monohydrate

产品活性：Quinidine hydrochloride monohydrate 是一种抗心律失常剂，也是 K⁺ 通道 (K⁺ channel) 的有效阻断剂，其 IC₅₀ 值为 19.9 μM。Quinidine hydrochloride monohydrate 是一种有效且选择性的细胞色素 P450db (cytochrome P450db) 抑制剂，也可用作疟疾的研究。

研究领域：Membrane Transporter/Ion Channel  |  Anti-infection

作用靶点：Potassium Channel  |  Parasite

In Vitro: Quinidine hydrochloride monohydrate blocks WT mSlo3 (K_Ca5.1) channels with an IC₅₀ of 19.9±1.41?μM and Hill slope of 1.15±0.15 (n=7). Again, the potency of inhibition by Quinidine hydrochloride monohydrate is higher for F304Y mSlo3 (IC₅₀ of 2.42±0.60?μM, n=9, P<0.005; Hill slope of 0.98±0.12), but lower with R196Q mSlo3 (IC₅₀ of 38.4±6.77?μM, n=5, P<0.001; Hill slope of 1.05±0.16). The inhibition of F304Y mSlo3 by Quinidine hydrochloride monohydrate is observed to have some time dependence.

In Vivo: Direct application of Quinidine hydrochloride monohydrate on the sciatic nerve produces a dose-related decrease in amplitude at ascending somato-sensory evoked potential (SSEP) and descending compound muscle action potentials (CMAP) when comparing baseline with other time points, or when comparing the experimental left limb to the right contra-lateral glucose-treated limb. The latencies of SSEPs and CMAP potentials after Quinidine hydrochloride monohydrate applications are increased compare to baseline and the contralateral side.

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