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Asiaticoside

CAS No. : 16830-15-2

MCE 站：Asiaticoside

产品活性：Asiaticoside 是从积雪草中分到的三萜皂苷化合物，在瘢痕疙瘩成纤维细胞中，通过活化 Smad7，抑制 TGF-βRI 和 TGF-βRII，抑制 TGF-β/Smad 信号通路；Asiaticoside 具有抗氧化、抗炎、抗溃疡等功效。

研究领域：Stem Cell/Wnt  |  TGF-beta/Smad  |  Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：TGF-beta/Smad  |  Reactive Oxygen Species  |  Apoptosis  |  Endogenous Metabolite

In Vitro: Asiaticoside (0, 100, 250, and 500 mg/L) dose-dependently inhibits keloid fibroblasts proliferation. Asiaticoside (100, 250, and 500 mg/L) decreases the expression of collagen protein and mRNA, reduces the expression of TGF-bRI, TGF-bRII protein, and mRNA, increases the expression of Smad7, but does not affect Smad2, Smad3, Smad4, phosphorylated Smad2, and phosphorylated Smad3 in keloid fibroblasts. Asiaticoside (12.5 and 50, and 25 and 50 ?g/mL) prevents endothelial cells from hypoxia-induced inhibition of cell viability and NO production. Asiaticoside (50 ?g/mL) also protects endothelial cells from hypoxia-induced apoptosis and upregulates and phosphorylation of AKT/eNOS in hypoxia-exposed HPAECs.

In Vivo: Asiaticoside (50 mg/kg daily) blocks the development of hypoxic pulmonary hypertension (PH), cardiovascular remodeling and endothelial cell injury in rats with pulmonary hypertension. Asiaticoside (5, 15 or 45 mg/kg, p.o.) improves the learning and memory deficit, protects hippocampi against the impairment, decreases Aβ deposits in the hippocampus, and ameliorates impaired subcellular structure in rats treated with Aβ oligomers.

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