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C3a 70-77

CAS No. : 63555-63-5

MCE 站：C3a 70-77

产品活性：C3a (70-77) 是对应于C3a的COOH末端的八肽，表现出C3a的特异性和1至2％的生物活性。

研究领域：Immunology/Inflammation

作用靶点：Complement System

In Vitro: The direct interaction of C3a(70-77) with human mononuclear leukocytes in culture results in a concentration-dependent inhibition of the generation of LIF evoked by mitogens and by the antigen SK-SD. The extent of suppression of LIF generation by C3a(70-77) is significant at concentrations of 10^-7 M or higher and exceeds 75% at 10^-6 M, irrespective of the stimulus.
C3a (70-77) induces histamine release and degranulation of rat mast cells, promotes contraction of guinea pig ileal tissue, and enhances vascular permeability in human skin. C3a (70-77) selectively desensitizes ileal smooth muscle to C3a but not to human C5a, a related anaphylatoxin. Conversely, C3a-(70-77) is unable to contract ileal smooth muscle pretreated with natural C3a. This cross-desensitization indicates a specific interaction of C3a (70-77) with cellular C3a binding sites.

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