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Saikogenin A

CAS No. : 5092-09-1

MCE 站：Saikogenin A

产品活性：Saikogenin A 可从中药柴胡中提取，是一种二肽基肽酶 IV (DPP-IV) 抑制剂。

研究领域：Metabolic Enzyme/Protease

作用靶点：Dipeptidyl Peptidase

In Vitro: Saikogenin A has certain inhibitory effect on the enzyme DPP-IV. At a concentration of 20 μg/mL DPP-IV inhibition is 47.6%. DPP-IV is a non-classical serine aminopeptidase from its amino terminus of polypeptides and proteins (N-terminus) removing Xaa-Pro dipeptide.

In Vivo: Saikogenin A, an anti-inflammatory drug, is present in the crude extract of a Chinese herbal plant called Tsai-Fu. Saikogenin A is less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema. The anti-inflammatory action of Saikogenin A are due to an increase in corticosterone caused by the release of arenocorticotropic hormone (ACTH) and a direct effect on the process of inflammation.

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