MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA

CAS No. :

MCE 站：Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA

产品活性：Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA) 是一种由 37 个氨基酸组成的降钙素家族神经肽，通过 (CRLR) 起作用。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：CGRP Receptor

In Vitro: Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA) belongs to the calcitonin family of neuropeptides which also includes adrenomedullin, amylin, calcitonin, intermedin and calcitonin receptor-stimulating peptide. Calcitonin Gene Related Peptide (CGRP) has two isoforms (αCGRP and βCGRP), and acts through calcitonin receptor-like receptor (CRLR). Calcitonin Gene Related Peptide (CGRP) plays a key role in migraine pathophysiology and is associated with activation of the trigeminovascular system. CGRP prossibly acts postjunctionally in these areas putatively involved in primary headaches.

In Vivo: Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA) is a potent inducer of oedema in rat orofacial tissue. CGRP (100 μL; 8-33 pM) induces a rapidly developing (5-15?min) and long-lasting (6?h), dose-dependent oedema in the rat cheek. CGRP induces a smaller oedematogenic effect in the rat hind paw also blocked by the CGRP antagonist. CGRP (16 pM) potentiates the oedema induced by co-injected substance P (3.7 nM).

相关产品：Bioactive Compound Library Plus  |  Olcegepant  |  Calcitonin (salmon)  |  Rat CGRP-(8-37)  |  β-CGRP, human TFA  |  Adrenomedullin (AM) (22-52), human  |  Ubrogepant  |  Calcitonin (human)  |  HCGRP-(8-37)  |  Adrenomedullin (11-50), rat  |  Adrenomedullin (16-31), human  |  Kendomycin  |  PHM-27 (human)  |  Adrenomedullin (1-50), rat  |  Calcitonin Gene Related Peptide (CGRP) (83-119), rat  |  CGRP antagonist 1

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。