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产品价格:电议      采购度:1600      原产地:美洲
发布时间:2021/7/23 19:08:59 所属地区:上海 上海市
简要描述:
GLP-1(7-36), amide 是刺激胰岛素分泌的生理性肠降血糖素。
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CAS No. : 107444-51-9
MCE 站:GLP-1(7-36), amide
产品活性:GLP-1(7-36), amide 是刺激胰岛素分泌的生理性肠降血糖素。
研究领域:GPCR/G Protein
作用靶点:Glucagon Receptor
In Vitro: The sequence of Glucagon-Like Peptide after residue 7 shows similarities to glucagon and to other biologically active members of the secretin peptide family, particularly glucose-dependent insulinotropic peptide (GIP). This sequence has been especially well preserved, showing 66% nucleotide homology with GLP-1 in the proglucagon of the very primitive anglerfish. This 7-36 sequence of GLP-1 is a potent insulin-releasing peptide in vitro. Glucagon-Like Peptide (GLP) I (7-36), amide is a product of the tissue-specific post-translational processing of the glucagon precursor. It is released postprandially from intestinal endocrine L cells and stimulates insulin secretion. DPP IV is the main degradation enzyme for GLP-l(7 - 36)amide in human serum. Dipeptidyl-peptidase IV can initiate the metabolism of GIP and GLP-1(7-36)amide in human serum.
In Vivo: Glucagon-Like Peptide (GLP) I (7-36), amide is a physiological incretin hormone that is released after nutrient intake from the lower gut and stimulates insulin secretion at elevated plasma glucose concentrations. Exogenous GLP-1 (7-36 amide) is an effective means of normalizing fasting plasma glucose concentrations in poorly-controlled Type 2 diabetic subjects. Exogenously administered GLP-1-(7–36)amide is extremely labile in vivo, with more than 80% being cleaved into GLP-1-(9–36)amide after sc or iv administration.
相关产品:Exendin-4 | Liraglutide | Glucagon (1-29), bovine, human, porcine | Avexitide | Adomeglivant | GLP-1(7-37) | GLP-1(7-36), amide acetate | BETP | GLP-2(1-33)(human) | GRA Ex-25 | NNC-0640 | Cotadutide acetate | Glucagon-like peptide 1 (1-37), human TFA | Taspoglutide | GLP-1 moiety from Dulaglutide | Glucagon receptor antagonists-3 | GLP-1(9-36)amide | GLP-2(3-33) | Exendin-3/4 (59-86) | FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS | GLP-1(28-36)amide | GLP-1(32-36)amide | GLP-1R Antagonist 1 | Glucagon receptor antagonists-1 | GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS | HAEGTFT
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更新时间:2024/1/2 10:14:16
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