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Spaglumic Acid

CAS No. : 3106-85-2

MCE 站：Spaglumic Acid

产品活性：Spaglumic Acid (N-Acetylaspartylglutamic acid) 是一种在脑中以毫摩尔浓度存在的神经肽。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

In Vitro: Spaglumic Acid (N-Acetylaspartylglutamate; NAAG) is released upon depolarization by a Ca²⁺-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. Spaglumic Acid is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of Spaglumic Acid and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders.

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