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Trigonelline

CAS No. : 535-83-1

MCE 站：Trigonelline

产品活性：Trigonelline 是一种大量存在于咖啡中并且具有潜在抗糖尿病活性的生物碱。Trigonelline 是一种有效的 Nrf2 抑制剂，可阻断 Nrf2 依赖的蛋白酶体活性，从而增强胰腺癌细胞凋亡。

研究领域：Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Endogenous Metabolite  |  Ferroptosis  |  Apoptosis

In Vitro: It is found that Trigonelline (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline attenuates H₂O₂ induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H₂O₂ induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirms that Trigonelline significantly reduces the H₂O₂ induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline concentration against H₂O₂ can induce the necrosis and apoptosis along with H₂O₂.

In Vivo: Trigonelline decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats.

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