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Allosteric Kinase Library

MCE 站：Allosteric Kinase Library

Allosteric kinase inhibition is among the most promising and sensitive deactivation mechanism of kinase activity. A unique collection of 4,800 carefully selected molecules via docking and visual evaluation has been offered.

Description & Advantages:

?   A unique collection of 4,800 carefully selected molecules via docking and visual evaluation.

?   Four type of possible allosteric kinase pockets were determined by now: 1) Myristoyl pocket; 2) Inhibitor binding mode that occupies part of binding pocket adjacent to the ATP-site; 3) PIF-pocket (regulatory site targeted); 4) pocket type I 1/2 relatively allosteric regulators of kinases (library contains 500 such compounds, only).

?   Structurally diverse.

?   No PAINS (Pan Assay Interference Compounds).

?   NMR and HPLC validated to ensure high purity and quality.

?   All compounds can be readily followed with analogues either from stock or from new syntheses.

?   Databases and compounds are provided by Enamine.

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