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CNS Library

MCE 站：CNS Library

A unique collection of 56,320 novel small molecules with high CNS MPO (Central Nervous System Multiparameter Optimization) scores. The CNS-active molecules which are able to penetrate blood-brain barrier (BBB) were low polar surface area, low degree of possible hydrogen bond formation and low ClogP values.

Description & Advantages:

?   A unique collection of 56,320 diverse compounds with desirable CNS properties.

?   CNS MPO ≥ 4, MW ≤ 350 (median value 283, cf. 305 for the marketed CNS drugs), ClogP ≤ 3.0 (mean value 1.63, cf. 2.8 for the marketed CNS drugs), Amide groups ≤ 1, Hbond Donor ≤ 2, QProp CNS value > 0.

?   The set was enriched with recently synthesized molecules having sp3-rich saturated ring cores of various architectures including spirocyclic (1,341 compounds, 14.5%), bridged and fused scaffolds (4,106 compounds, 44.5%).

?   Targets such as Kinases, GPCR and Ion Channels, and more.

?   A useful tool for the discovery of drugs used for brain diseases, such as brain tumors, mental disorders, and neurodegenerative diseases.

?   NMR and HPLC validated to ensure high purity and quality.

?   All compounds can be readily followed with analogues either from stock or from new syntheses.

?   Databases and compounds are provided by Enamine.

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。