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Rentiapril racemate

CAS No. : 72679-47-1

MCE 站：Rentiapril racemate

产品活性：Rentiapril racemate (SA-446 racemate) 是 Rentiapril 的外消旋体。Rentiapril 是一种血管紧张素转换酶 (ACE) 抑制剂。

研究领域：Metabolic Enzyme/Protease

作用靶点：Angiotensin-converting Enzyme (ACE)

In Vivo: A three-months toxicity study of an angiotensin converting enzyme (ACE) inhibitor, Rentiapril (CAS 80830-42-8), is performed in Sprague-Dawley rats by oral administration. The dose levels of 0, 30, 125, 500 and 1000 mg/kg are tested in both sexes, in which each experimental group comprised 10 rats. Another ACE inhibitor, captopril, is used as a reference compound. Rentiapril at the highest dose of 1000 mg/kg causes low food consumption and death of some animals with signs of bloody feces and anemia. In males and females receiving 500 and 1000 mg/kg, there are low body weight gain, increases in water intake, urine volume and serum BUN level, and decreases in levels of various erythrocytic parameters. Kidney weight is increased dose-dependently in both sexes. Histopathologically, renal changes in the 500 and 1000 mg/kg groups consist of proximal tubular degeneration, juxtaglomerular cell hyperplasia and interstitial cell infiltration. Similar, but mild, changes in proximal tubules are present in the female 125 mg/kg group. Dead animals from the highest dose groups further show gastrointestinal hemorrhagic erosion and/or ulcer, decrease bone marrow erythropoiesis and hepatocytic vacuolar degeneration. There is no pathological alteration in rats from other Rentiapril-treated groups, as well as in controls. These results indicate that the no-effect dose of Rentiapril in rats by three months oral administration is 30 mg/kg in female and 125 mg/kg in male.

相关产品：MLN-4760  |  Angiotensin (1-7)  |  Captopril  |  Enalapril maleate  |  Diminazene aceturate  |  Lisinopril dihydrate  |  Perindopril erbumine  |  Fosinopril sodium  |  Sinapinic acid  |  Benazepril hydrochloride  |  Omapatrilat  |  Quinapril hydrochloride  |  Ramipril  |  Moexipril hydrochloride  |  Phosphoramidon Disodium  |  Deserpidine  |  Enalaprilat dihydrate  |  Cilazapril monohydrate  |  Resorcinolnaphthalein  |  Trandolapril  |  Delapril hydrochloride  |  Imidapril hydrochloride  |  Zofenopril calcium  |  H-Ile-Pro-Pro-OH hydrochloride  |  Alamandine  |  N-Acetyl-Ser-Asp-Lys-Pro TFA  |  Temocapril hydrochloride  |  BML-111

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