MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Deramciclane

CAS No. : 120444-71-5

MCE 站：Deramciclane

产品活性：Deramciclane 对 5-HT_2A 和 5-HT_2C 受体具有高亲和力。Deramciclane 作为两种受体亚型的拮抗剂，对 5-HT_2C 受体具有反向激动剂特性，无直接刺激激动剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：5-HT Receptor

In Vitro: Deramciclane is a novel anxiolytic agent that binds with high affinity to 5-HT_2A/_2C receptors. The interactions of Deramciclane with the serotonin 5-HT_2C receptor are characterized further using receptor phosphoinositide hydrolysis assays and receptor autoradiography. Deramciclane antagonizes 5-HT_2C receptor mediated 5-HT-stimulated phosphoinositide hydrolysis with an IC₅₀ value of 168 nM. Deramciclane also decreases basal phosphoinositide hydrolysis by up to 33% (EC₅₀= 93 nM) in a physiological system in the choroid plexus, suggesting that Deramciclane possesses inverse agonist properties at this receptor.

In Vivo: Deramciclane 3 and 10 mg/kg does not change the dopamine levels significantly at any time point versus the basal level whereas 30 mg/kg of Deramciclane significantly increases the levels at 40-100 min and at 160-240 min (P<0.05). Deramciclane is a putative antiserotonergic compound that reduces 5-HT-induced phosphoinositol hydrolysis and a variety of actions caused by serotonergic agonists. The receptor binding profile of Deramciclane is rather similar to that of ritanserin. Deramciclane has a high affinity for 5-HT_2A and 5-HT_2C receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT_2C receptors without direct stimulatory agonist effects. Deramciclane has been shown to have anxiolytic-like activity in several animal tests.

相关产品：Harmine  |  SCH-23390 hydrochloride  |  Puerarin  |  Olanzapine  |  GTS-21 dihydrochloride  |  Thioridazine hydrochloride  |  Risperidone  |  SB-269970 hydrochloride  |  Dihydroergotamine mesylate  |  Amitriptyline hydrochloride  |  Aripiprazole  |  Ketanserin  |  WAY-100635 Maleate  |  Buspirone hydrochloride  |  Cisapride  |  Methiothepin mesylate  |  Trazodone hydrochloride  |  Pindolol  |  Quetiapine  |  Lumateperone tosylate  |  Perphenazine  |  8-OH-DPAT  |  Levomepromazine  |  SB-224289 hydrochloride  |  Volinanserin  |  Ziprasidone  |  Paliperidone  |  Sertindole  |  Alprenolol hydrochloride  |  Asenapine maleate

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。