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Abaperidone

CAS No. : 183849-43-6

MCE 站：Abaperidone

产品活性：Abaperidone 是一种有效的 5-HT_2A 受体和多巴胺 D₂ 受体拮抗剂，IC₅₀ 分别为 6.2 和 17 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Dopamine Receptor  |  5-HT Receptor

In Vitro: Abaperidone possesses good affinity for dopamine D₂ receptors, together with a greater affinity for 5-HT₂ receptors with IC₅₀ of 17 and 6.2 nM, reaspectively.

In Vivo: The time course of the inhibition of climbing behavior for a period of several hours after oral administration of either 0.5 mg/kg of Abaperidone or risperidone is tested in mice. Also is included a comparative test of catalepsy induced by Abaperidone and risperidone along several hours following oral administration at several doses in rats. A somewhat lesser induction of catalepsy is observed for Abaperidone. A study of serum prolactin levels after oral administration of Abaperidone, haloperidol, and risperidone at 5 mg/kg for either 1 or 3 days in rats. Increases in prolactin levels after oral administration of Abaperidone are smaller than those for reference drugs.

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